Nuclear Localization of BMP2

Nuclear localization of SALL4

in 2006, yamanaka et al. reported the generation of induced pluripotent stem cells (iPsc) from somatic tissue with the introduction of just 4 transcription factors: Oct4, sox2, Klf4, and c-Myc.1 The finding, with its promise of autologous therapy, was the beginning of a vast and unprecedented effort to better understand the epigenetic basis of pluripotency and of “stemness.”2 sALL4 is a zinc fi...

Finding nuclear localization signals.

A variety of nuclear localization signals (NLSs) are experimentally known although only one motif was available for database searches through PROSITE. We initially collected a set of 91 experimentally verified NLSs from the literature. Through iterated 'in silico mutagenesis' we then extended the set to 214 potential NLSs. This final set matched in 43% of all known nuclear proteins and in no kn...

Nuclear localization of mouse Mx

Predicting nuclear localization.

Nuclear localization of proteins is a crucial element in the dynamic life of the cell. It is complicated by the massive diversity of targeting signals and the existence of proteins that shuttle between the nucleus and cytoplasm. Nevertheless, a majority of subcellular localization tools that predict nuclear proteins have been developed without involving dual localized proteins in the data sets....

Regulation of Phytochrome B Nuclear Localization through Light-Dependent Unmasking of Nuclear-Localization Signals

Phytochromes are red and far-red photoreceptors that regulate plant growth and development in response to environmental light cues. Phytochromes exist in two photo-interconvertible conformational states: an inactive Pr form and an active Pfr form. The alteration of phytochromes' subcellular location functions as a major regulatory mechanism of their biological activities. Whereas phytochromes i...